Allison Elizabeth Ashley-Koch, PhD


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Professor in Medicine
Research Professor in Molecular Genetics and Microbiology
Professor in Biostatistics and Bioinformatics
Department / Division:
Medicine / Medicine-Nephrology
300 N Duke St.
Durham, NC 27701
Office Telephone:
(919) 684-1805
  • PhD, Emory University, 1997
Research Interests:
One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.
Representative Publications:
  • Markunas, CA; Quinn, KS; Collins, AL; Garrett, ME; Lachiewicz, AM; Sommer, JL; Morrissey-Kane, E; Kollins, SH; Anastopoulos, AD; Ashley-Koch, AE. Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families. Psychiatric Genetics. 2010;20:73-81.  Abstract
  • Sebastiani, P; Solovieff, N; Hartley, SW; Milton, JN; Riva, A; Dworkis, DA; Melista, E; Klings, ES; Garrett, ME; Telen, MJ; Ashley-Koch, A; Baldwin, CT; Steinberg, MH. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. American Journal of Hematology. 2010;85:29-35.  Abstract
  • Taylor, WD; Steffens, DC; Ashley-Koch, A; Payne, ME; MacFall, JR; Potocky, CF; Krishnan, KR. Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men. Molecular Psychiatry. 2010;15:816-822.  Abstract
  • Kollins, SH; Garrett, ME; McClernon, FJ; Lachiewicz, AM; Morrissey-Kane, E; FitzGerald, D; Collins, AL; Anastopoulos, AD; Ashley-Koch, AE. Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms. Journal of Nervous and Mental Disease. 2009;197:442-449.  Abstract
  • Z├╝chner, S; Wendland, JR; Ashley-Koch, AE; Collins, AL; Tran-Viet, KN; Quinn, K; Timpano, KC; Cuccaro, ML; Pericak-Vance, MA; Steffens, DC; Krishnan, KR; Feng, G; Murphy, DL. Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Molecular Psychiatry. 2009;14:6-9.  Abstract
  • Ashley-Koch, AE; Elliott, L; Kail, ME; De Castro, LM; Jonassaint, J; Jackson, TL; Price, J; Ataga, KI; Levesque, MC; Weinberg, JB; Orringer, EP; Collins, A; Vance, JM; Telen, MJ. Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood. 2008;111:5721-5726.  Abstract
  • Deak, KL; Siegel, DG; George, TM; Gregory, S; Ashley-Koch, A; Speer, MC; NTD Collaborative Group. Further evidence for a maternal genetic effect and a sex-influenced effect contributing to risk for human neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology. 2008;82:662-669.  Abstract
  • Ashley-Koch, AE; Jaworski, J; Ma, DQ; Mei, H; Ritchie, MD; Skaar, DA; Robert Delong, G; Worley, G; Abramson, RK; Wright, HH; Cuccaro, ML; Gilbert, JR; Martin, ER; Pericak-Vance, MA. Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. Psychiatric Genetics. 2007;17:221-226.  Abstract
  • Zuchner, S; Cuccaro, ML; Tran-Viet, KN; Cope, H; Krishnan, RR; Pericak-Vance, MA; Wright, HH; Ashley-Koch, A. SLITRK1 mutations in trichotillomania. Molecular Psychiatry. 2006;11:887-889.  Abstract