Kouros Owzar, PhD

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Associate Professor of Biostatistics and Bioinformatics
Department:
Biostatistics & Bioinformatics
Address:
2424 Erwin Road Suite 1102
11074 Hock Plaza
Durham, NC 27705
Office Telephone:
(919) 681-1829
Training:
  • PhD, University of North Carolina at Chapel Hill, 2002
Research Interests:
statistical genetics
statistical methods for high-dimensional data
pharmacogenomics
copulas
survival analysis
statistical computing
Representative Publications:
  • Baldwin, RM; Owzar, K; Zembutsu, H; Chhibber, A; Kubo, M; Jiang, C; Watson, D; Eclov, RJ; Mefford, J; McLeod, HL; Friedman, PN; Hudis, CA; Winer, EP; Jorgenson, EM; Witte, JS; Shulman, LN; Nakamura, Y; Ratain, MJ; Kroetz, DL. A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. Clinical Cancer Research. 2012;18:5099-5109.  Abstract
  • Innocenti, F; Owzar, K; Cox, NL; Evans, P; Kubo, M; Zembutsu, H; Jiang, C; Hollis, D; Mushiroda, T; Li, L; Friedman, P; Wang, L; Glubb, D; Hurwitz, H; Giacomini, KM; McLeod, HL; Goldberg, RM; Schilsky, RL; Kindler, HL; Nakamura, Y; Ratain, MJ. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clinical Cancer Research. 2012;18:577-584.  Abstract
  • Kelsey, CR; Jackson, L; Langdon, S; Owzar, K; Hubbs, J; Vujaskovic, Z; Das, S; Marks, LB. A polymorphism within the promoter of the TGFß1 gene is associated with radiation sensitivity using an objective radiologic endpoint. International Journal of Radiation: Oncology - Biology - Physics. 2012;82:e247-e255.  Abstract
  • McCarthy, PL; Owzar, K; Hofmeister, CC; Hurd, DD; Hassoun, H; Richardson, PG; Giralt, S; Stadtmauer, EA; Weisdorf, DJ; Vij, R; Moreb, JS; Callander, NS; Van Besien, K; Gentile, T; Isola, L; Maziarz, RT; Gabriel, DA; Bashey, A; Landau, H; Martin, T; Qazilbash, MH; Levitan, D; McClune, B; Schlossman, R; Hars, V; Postiglione, J; Jiang, C; Bennett, E; Barry, S; Bressler, L; Kelly, M; Seiler, M; Rosenbaum, C; Hari, P; Pasquini, MC; Horowitz, MM; Shea, TC; Devine, SM; Anderson, KC; Linker, C. Lenalidomide after stem-cell transplantation for multiple myeloma. New England Journal of Medicine. 2012;366:1770-1781.  Abstract
  • Owzar, K; Li, Z; Cox, N; Jung, SH. Power and sample size calculations for SNP association studies with censored time-to-event outcomes. Genetic Epidemiology. 2012;36:538-548.  Abstract
  • Roberts, AS; Campa, MJ; Gottlin, EB; Jiang, C; Owzar, K; Kindler, HL; Venook, AP; Goldberg, RM; O'Reilly, EM; Patz, EF. Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303). Cancer. 2012;118:571-578.  Abstract
  • Bashey, A; Owzar, K; Johnson, JL; Edwards, PS; Kelly, M; Baxter-Lowe, LA; Devine, S; Farag, S; Hurd, D; Ball, E; McCarthy, P; Lister, J; Shea, TC; Linker, C. Reduced-intensity conditioning allogeneic hematopoietic cell transplantation for patients with hematologic malignancies who relapse following autologous transplantation: a multi-institutional prospective study from the Cancer and Leukemia Group B (CALGB trial 100002). Biology of Blood and Marrow Transplantation. 2011;17:558-565.  Abstract
  • Frahm, M; Goswami, ND; Owzar, K; Hecker, E; Mosher, A; Cadogan, E; Nahid, P; Ferrari, G; Stout, JE. Discriminating between latent and active tuberculosis with multiple biomarker responses. Tuberculosis. 2011;91:250-256.  Abstract
  • Klymenko, SV; Belyi, DA; Ross, JR; Owzar, K; Jiang, C; Li, Z; N Minchenko, J; N Kovalenko, A; Bebeshko, VG; J Chao, N. Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident. International Journal of Radiation Biology. 2011;87:846-850.  Abstract
  • Lewis, DA; Stashenko, GJ; Akay, OM; Price, LI; Owzar, K; Ginsburg, GS; Chi, JT; Ortel, TL. Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism. Thrombosis Research. 2011;128:536-540.  Abstract
  • McCarthy, PL; Owzar, K; Anderson, K. "Sowing dragon's teeth?" Myeloma and AML. Blood. 2011;118:4008-4009.  Abstract
  • Mitha, F; Herodotou, H; Borisov, N; Jiang, C; Yoder, J; Owzar, K. SNPpy--database management for SNP data from genome wide association studies. PLoS One. 2011;6:e24982.  Abstract
  • Owzar, K; Barry, WT; Jung, SH. Statistical considerations for analysis of microarray experiments. Clinical and Translational Science. 2011;4:466-477.  Abstract
  • Shea, T; Johnson, J; Westervelt, P; Farag, S; McCarty, J; Bashey, A; Isola, L; Baxter-Lowe, LA; Kelly, M; Owzar, K; Linker, C; Cancer and Leukemia Group B. Reduced-intensity allogeneic transplantation provides high event-free and overall survival in patients with advanced indolent B cell malignancies: CALGB 109901. Biology of Blood and Marrow Transplantation. 2011;17:1395-1403.  Abstract
  • Sohn, I; Owzar, K; Lim, J; George, SL; Mackey Cushman, S; Jung, SH. Multiple testing for gene sets from microarray experiments. BMC Bioinformatics. 2011;12:209.  Abstract
  • Chen, BJ; Deoliveira, D; Spasojevic, I; Sempowski, GD; Jiang, C; Owzar, K; Wang, X; Gesty-Palmer, D; Cline, JM; Bourland, JD; Dugan, G; Meadows, SK; Daher, P; Muramoto, G; Chute, JP; Chao, NJ. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One. 2010;5:e11056.  Abstract
  • Civantos, FJ; Zitsch, RP; Schuller, DE; Agrawal, A; Smith, RB; Nason, R; Petruzelli, G; Gourin, CG; Wong, RJ; Ferris, RL; El Naggar, A; Ridge, JA; Paniello, RC; Owzar, K; McCall, L; Chepeha, DB; Yarbrough, WG; Myers, JN. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. Journal of Clinical Oncology. 2010;28:1395-1400.  Abstract
  • Gauter-Fleckenstein, B; Fleckenstein, K; Owzar, K; Jiang, C; Rebouças, JS; Batinic-Haberle, I; Vujaskovic, Z. Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage. Free Radical Biology and Medicine. 2010;48:1034-1043.  Abstract
  • Halabi, S; Owzar, K. The importance of identifying and validating prognostic factors in oncology. Seminars in Oncology. 2010;37:e9-18.  Abstract
  • Shterev, ID; Jung, SH; George, SL; Owzar, K. permGPU: Using graphics processing units in RNA microarray association studies. BMC Bioinformatics. 2010;11:329.  Abstract
  • Sohn, I; Owzar, K; George, SL; Kim, S; Jung, SH. Robust test method for time-course microarray experiments. BMC Bioinformatics. 2010;11:391.  Abstract
  • Dematteo, RP; Ballman, KV; Antonescu, CR; Maki, RG; Pisters, PW; Demetri, GD; Blackstein, ME; Blanke, CD; von Mehren, M; Brennan, MF; Patel, S; McCarter, MD; Polikoff, JA; Tan, BR; Owzar, K; American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet. 2009;373:1097-1104.  Abstract
  • Halabi, S; Vogelzang, NJ; Ou, SS; Owzar, K; Archer, L; Small, EJ. Progression-free survival as a predictor of overall survival in men with castrate-resistant prostate cancer. Journal of Clinical Oncology. 2009;27:2766-2771.  Abstract
  • Lambotte, O; Ferrari, G; Moog, C; Yates, NL; Liao, HX; Parks, RJ; Hicks, CB; Owzar, K; Tomaras, GD; Montefiori, DC; Haynes, BF; Delfraissy, JF. Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers. AIDS. 2009;23:897-906.  Abstract
  • Linker, CA; Owzar, K; Powell, B; Hurd, D; Damon, LE; Archer, LE; Larson, RA; Cancer and Leukemia Group B. Auto-SCT for AML in second remission: CALGB study 9620. Bone Marrow Transplantation. 2009;44:353-359.  Abstract
  • Miller, AA; Murry, DJ; Owzar, K; Hollis, DR; Kennedy, EB; Abou-Alfa, G; Desai, A; Hwang, J; Villalona-Calero, MA; Dees, EC; Lewis, LD; Fakih, MG; Edelman, MJ; Millard, F; Frank, RC; Hohl, RJ; Ratain, MJ. Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. Journal of Clinical Oncology. 2009;27:1800-1805.  Abstract
  • Sohn, I; Owzar, K; George, SL; Kim, S; Jung, SH. A permutation-based multiple testing method for time-course microarray experiments. BMC Bioinformatics. 2009;10:336.  Abstract
  • Demark-Wahnefried, W; Polascik, TJ; George, SL; Switzer, BR; Madden, JF; Ruffin, MT; Snyder, DC; Owzar, K; Hars, V; Albala, DM; Walther, PJ; Robertson, CN; Moul, JW; Dunn, BK; Brenner, D; Minasian, L; Stella, P; Vollmer, RT. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiology, Biomarkers and Prevention. 2008;17:3577-3587.  Abstract
  • Gauter-Fleckenstein, B; Fleckenstein, K; Owzar, K; Jiang, C; Batinic-Haberle, I; Vujaskovic, Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radical Biology and Medicine. 2008;44:982-989.  Abstract
  • Heinrich, MC; Owzar, K; Corless, CL; Hollis, D; Borden, EC; Fletcher, CD; Ryan, CW; von Mehren, M; Blanke, CD; Rankin, C; Benjamin, RS; Bramwell, VH; Demetri, GD; Bertagnolli, MM; Fletcher, JA. Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group. Journal of Clinical Oncology. 2008;26:5360-5367.  Abstract
  • Owzar, K. Alternate statistical tools and limitations in genetic marker association studies in single-arm drug cancer trials. Journal of Clinical Oncology. 2008;26:1400-1401.  Abstract
  • Owzar, K; Barry, WT; Jung, SH; Sohn, I; George, SL. Statistical challenges in preprocessing in microarray experiments in cancer. Clinical Cancer Research. 2008;14:5959-5966.  Abstract
  • Owzar, K; Jung, SH. Designing phase II studies in cancer with time-to-event endpoints. Clinical Trials. 2008;5:209-221.  Abstract
  • Miller, AA; Murry, DJ; Owzar, K; Hollis, DR; Lewis, LD; Kindler, HL; Marshall, JL; Villalona-Calero, MA; Edelman, MJ; Hohl, RJ; Lichtman, SM; Ratain, MJ. Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101. Journal of Clinical Oncology. 2007;25:3055-3060.  Abstract
  • Owzar, K; Jung, SH; Sen, PK. A copula approach for detecting prognostic genes associated with survival outcome in microarray studies. Biometrics. 2007;63:1089-1098.  Abstract
  • Jung, SH; Owzar, K; George, SL; Lee, T. P-value calculation for multistage phase II cancer clinical trials. Journal of Biopharmaceutical Statistics. 2006;16:765-775.  Abstract
  • Sicklick, JK; Li, YX; Jayaraman, A; Kannangai, R; Qi, Y; Vivekanandan, P; Ludlow, JW; Owzar, K; Chen, W; Torbenson, MS; Diehl, AM. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis. 2006;27:748-757.  Abstract
  • Jung, SH; Owzar, K; George, SL. A multiple testing procedure to associate gene expression levels with survival. Statistics in Medicine. 2005;24:3077-3088.  Abstract
  • Skinner, MA; Moley, JA; Dilley, WG; Owzar, K; Debenedetti, MK; Wells, SA. Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. New England Journal of Medicine. 2005;353:1105-1113.  Abstract