Chi Wei Chan, MD, PhD

Department:
Biostatistics and Bioinformatics

Email Address:
cliburn.chan@duke.edu

Address:
DUMC Box 2721

Durham, NC 27710

Telephone:
9196682459

Fax Telephone:
9196682465

Research Interests:
Computational immunology (stochastic and spatial models and simulations, T cell signaling, immune regulation)
Statistical methodology for immunological laboratory techniques (flow cytometry, CFSE analysis, receptor-ligand binding and signaling kinetics)
Informatics of the immune system (reference and application ontologies, meta-programming, text mining and machine learning)

Publications:
2005 -- Chan C, Stark J and George AJT. The impact of multiple T cell–APC encounters and the role of anergy. Journal of Computational and Applied Mathematics, (2005) 184:101-120

2005 -- Pubmed # 16273530 -- Tan PH, Chan CL, Chan C, George AJ. The evolving role of gene-based treatment in surgery. Br J Surg. 2005 Dec;92(12):1466-80.

2005 -- Pubmed # 15944264 -- Tan PH, Sagoo P, Chan C, Yates JB, Campbell J, Beutelspacher SC, Foxwell BM, Lombardi G, George AJ. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol. 2005 Jun 15;174(12):7633-44.

2005 -- Pubmed # 15994283 -- Tan PH, Yates JB, Xue SA, Chan C, Jordan WJ, Harper JE, Watson MP, Dong R, Ritter MA, Lechler RI, Lombardi G, George AJ. Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. Blood. 2005 Nov 1;106(9):2936-43.

2004 -- Pubmed # 15041406 -- Chan C, Lechler RI, George AJ. Tolerance mechanisms and recent progress. Transplant Proc. 2004 Mar;36(2 Suppl):561S-569S.

2004 -- Pubmed # 15255048 -- Chan C, Stark J, George AJ. Feedback control of T-cell receptor activation. Proc Biol Sci. 2004 May 7;271(1542):931-9.

2004 -- Pubmed # 15064090 -- Tan PH, Chan C, Xue SA, Dong R, Ananthesayanan B, Manunta M, Kerouedan C, Cheshire NJ, Wolfe JH, Haskard DO, Taylor KM, George AJ. Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells. Atherosclerosis. 2004 Apr;173(2):171-83.

2003 -- Chan C, George AJT and Stark J, T cell sensitivity and specificity – kinetic proofreading revisited. Discrete and Continuous Dynamical Systems – Series B, 3, (2003), 343-360.

2001 -- Pubmed # 11344310 -- Chan C, George AJ, Stark J. Cooperative enhancement of specificity in a lattice of T cell receptors. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5758-63.

1999 -- Pubmed # 10649636 -- Chan CC, Stark J, George AJ. Analysis of cytokine dynamics in corneal allograft rejection. Proc Biol Sci. 1999 Nov 7;266(1434):2217-23.