Lindsay Cowell, PhD

Department:
Biostatistics and Bioinformatics

Email Address:
lgcowell@duke.edu

Telephone:
9196816226

Research Interests:
Somatic Diversification of Lymphocyte Antigen Receptor Genes
* V(D)J Recombination
* Somatic Hypermutation

Biomedical Ontology
* Ontological Representation of Cells of Hematopoietic Lineage

Biomedical Text Mining
Logic-based Reasoning

Publications:
2006 -- Pubmed # 16418189 -- Fadel SA, Cowell LG, Cao S, Ozaki DA, Kepler TB, Steeber DA, Sarzotti M. Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection. Int Immunol. 2006 Feb;18(2):249-57.

2006 -- Pubmed # 16054218 -- Larijani M, Chen S, Cunningham LA, Volpe JM, Cowell LG, Lewis SM, Wu GE. The recombination difference between mouse kappa and lambda segments is mediated by a pair-wise regulation mechanism. Mol Immunol. 2006 Mar;43(7):870-81.

2006 -- Pubmed # 16357034 -- Volpe JM, Cowell LG, Kepler TB. SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations. Bioinformatics. 2006 Feb 15;22(4):438-44.

2004 -- Pubmed # 15242396 -- Cowell LG, Davila M, Ramsden D, Kelsoe G. Computational tools for understanding sequence variability in recombination signals. Immunol Rev. 2004 Aug;200:57-69.

2003 -- Pubmed # 12538660 -- Cowell LG, Davila M, Yang K, Kepler TB, Kelsoe G. Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling. J Exp Med. 2003 Jan 20;197(2):207-20.

2003 -- Pubmed # 14551903 -- Lee AI, Fugmann SD, Cowell LG, Ptaszek LM, Kelsoe G, Schatz DG. A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol. 2003 Oct;1(1):E1.

2002 -- Pubmed # 12537561 -- Cowell LG, Davila M, Kepler TB, Kelsoe G. Identification and utilization of arbitrary correlations in models of recombination signal sequences. Genome Biol. 2002;3(12):RESEARCH0072.

2002 -- Pubmed # 12433370 -- Liang HE, Hsu LY, Cado D, Cowell LG, Kelsoe G, Schlissel MS. The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. Immunity. 2002 Nov;17(5):639-51.

2001 -- Pubmed # 11145665 -- Oprea M, Cowell LG, Kepler TB. The targeting of somatic hypermutation closely resembles that of meiotic mutation. J Immunol. 2001 Jan 15;166(2):892-9.

2000 -- Pubmed # 10657647 -- Cowell LG, Kepler TB. The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation. J Immunol. 2000 Feb 15;164(4):1971-6.

1999 -- Pubmed # 10368430 -- Cowell LG, Kim HJ, Humaljoki T, Berek C, Kepler TB. Enhanced evolvability in immunoglobulin V genes under somatic hypermutation. J Mol Evol. 1999 Jul;49(1):23-6.

1998 -- Pubmed # 9473394 -- Cowell LG, Crowder LB, Kepler TB. Density-dependent prenatal androgen exposure as an endogenous mechanism for the generation of cycles in small mammal populations J Theor Biol. 1998 Jan 7;190(1):93-106.

1998 -- Pubmed # 9477340 -- Cowell LG, Kepler TB, Janitz M, Lauster R, Mitchison NA. The distribution of variation in regulatory gene segments, as present in MHC class II promoters. Genome Res. 1998 Feb;8(2):124-34.