Lawrence Muhlbaier, PhD

Department:
Biostatistics and Bioinformatics

Email Address:
lawrence.muhlbaier@duke.edu

Address:
DUMC 3865

Durham, NC 27710-751

Telephone:
9196688774

Fax Telephone:
9196687057

Research Interests:
-- Evaluation of outcomes in cardiac surgical patients.
-- Validate statistical models of short and long term outcome of patients with IHD in non-academic databases.
-- Developing methods to present these evaluations so that they can be incorporated into patient care activities on an ongoing basis.
-- To understand the variability in the utilization of medical care services in ischemic heart disease (IHD).  Focus on Medicare cohorts for geologic, race, and sex differences.  Includes examining cost relationships in these data.
-- Methods to link data from clinical and research databases to effectively use the data for both purposes.
-- HIPAA and other regulatory systems and their impact on Research
-- Patient Privacy

Publications:
2009 -- Pubmed # 19464406 -- Dokholyan RS, Muhlbaier LH, Falletta JM, Jacobs JP, Shahian D, Haan CK, Peterson ED. Regulatory and ethical considerations for linking clinical and administrative databases. Am Heart J. 2009 Jun;157(6):971-82.

2009 -- Pubmed # 19185093 -- Eisenstein EL, Sun JL, Anstrom KJ, Stafford JA, Szczech LA, Muhlbaier LH, Mark DB. Do income level and race influence survival in patients receiving hemodialysis? Am J Med. 2009 Feb;122(2):170-80.

2009 -- Pubmed # 19199534 -- Kanafani ZA, Arduino JM, Muhlbaier LH, Kaye KS, Allen KB, Carmeli Y, Corey GR, Cosgrove SE, Fraser TG, Harris AD, Karchmer AW, Lautenbach E, Rupp ME, Peterson ED, Straus WL, Fowler VG Jr. Incidence of and preoperative risk factors for Staphylococcus aureus bacteremia and chest wound infection after cardiac surgery. Infect Control Hosp Epidemiol. 2009 Mar;30(3):242-8.

2008 -- Pubmed # 18283083 -- Armitage J, Souhami R, Friedman L, Hilbrich L, Holland J, Muhlbaier LH, Shannon J, Van Nie A. The impact of privacy and confidentiality laws on the conduct of clinical trials. Clin Trials. 2008;5(1):70-4.

2008 -- Pubmed # 18502534 -- Eisenstein EL, Sun JL, Anstrom KJ, Stafford JA, Szczech LA, Muhlbaier LH, Mark DB. Re-evaluating the volume-outcome relationship in hemodialysis patients. Health Policy. 2008 Dec;88(2-3):317-25.

2007 -- Pubmed # 17522334 -- Badruddoja MA, Keir ST, King I, Zeidner J, Vredenburgh JJ, Muhlbaier LH, Bigner DD, Friedman HS. Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice. Neuro Oncol. 2007 Jul;9(3):240-4.

2007 -- Pubmed # 17184638 -- Cowper PA, DeLong ER, Hannan EL, Muhlbaier LH, Lytle BL, Jones RH, Holman WL, Pokorny JJ, Stafford JA, Mark DB, Peterson ED. Is early too early? Effect of shorter stays after bypass surgery. Ann Thorac Surg. 2007 Jan;83(1):100-7.

2006 -- Pubmed # 17161075 -- Cowper PA, DeLong ER, Hannan EL, Muhlbaier LH, Lytle BL, Jones RH, Holman WL, Pokorny JJ, Stafford JA, Mark DB, Peterson ED. Trends in postoperative length of stay after bypass surgery. Am Heart J. 2006 Dec;152(6):1194-200.

2006 -- Illes J, Kirschen MP, Edwards E, Stanford LR, Bandettini P,Cho MK, Ford PJ, Glover GH, Kulynych J, Macklin R, Michael DB, Wolf SM and members of the Working Group on Incidental Findings in Brain Imaging Research.  Incidental Findings in Brain Imaging Research.  Science 2006 Feb 10, 311(5762):783-784

2006 -- Pubmed # 16644320 -- LaPointe NM, DeLong ER, Chen A, Hammill BG, Muhlbaier LH, Califf RM, Kramer JM. Multifaceted intervention to promote beta-blocker use in heart failure. Am Heart J. 2006 May;151(5):999-1005.

2006 -- Pubmed # 16847232 -- Moretti EW, Newman MF, Muhlbaier LH, Whellan D, Petersen RP, Rossignol D, McCants CB Jr, Phillips-Bute B, Bennett-Guerrero E. Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery. Arch Surg. 2006 Jul;141(7):637-41; discussion 642.

2006 -- Pubmed # 16401776 -- Newby LK, LaPointe NM, Chen AY, Kramer JM, Hammill BG, DeLong ER, Muhlbaier LH, Califf RM. Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease. Circulation. 2006 Jan 17;113(2):203-12.

2005 -- Pubmed # 15931798 -- Eisenstein EL, Bethea CF, Muhlbaier LH, Davidian M, Peterson ED, Stafford JA, Mark DB. Surgeons' economic profiles: can we get the "right" answers? J Med Syst. 2005 Apr;29(2):111-24.

2005 -- Pubmed # 16159846 -- Fowler VG Jr, O'Brien SM, Muhlbaier LH, Corey GR, Ferguson TB, Peterson ED. Clinical predictors of major infections after cardiac surgery. Circulation. 2005 Aug 30;112(9 Suppl):I358-65.

2005 -- Pubmed # 16359060 -- Rankin JS, Glower DD, Teichmann TL, Muhlbaier LH, Stratton CW. Immunotherapy for refractory pulmonary infection after adult cardiac surgery: immune dysregulation syndrome. J Heart Valve Dis. 2005 Nov;14(6):783-91.

2005 -- Pubmed # 16159834 -- Schroder JN, Williams ML, Hata JA, Muhlbaier LH, Swaminathan M, Mathew JP, Glower DD, O'Connor CM, Smith PK, Milano CA. Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary artery bypass grafting. Circulation. 2005 Aug 30;112(9 Suppl):I293-8.

2005 -- Pubmed # 16159847 -- Williams ML, Muhlbaier LH, Schroder JN, Hata JA, Peterson ED, Smith PK, Landolfo KP, Messier RH, Davis RD, Milano CA. Risk-adjusted short- and long-term outcomes for on-pump versus off-pump coronary artery bypass surgery. Circulation. 2005 Aug 30;112(9 Suppl):I366-70.

2004 -- Pubmed # 14685099 -- Guller U, Hervey S, Purves H, Muhlbaier LH, Peterson ED, Eubanks S, Pietrobon R. Laparoscopic versus open appendectomy: outcomes comparison based on a large administrative database. Ann Surg. 2004 Jan;239(1):43-52.

2004 -- Pubmed # 15118584 -- Guller U, Jain N, Peterson ED, Muhlbaier LH, Eubanks S, Pietrobon R. Laparoscopic appendectomy in the elderly. Surgery. 2004 May;135(5):479-88.

2004 -- Pubmed # 14759451 -- Smith PK, Datta SK, Muhlbaier LH, Samsa G, Nadel A, Lipscomb J. Cost analysis of aprotinin for coronary artery bypass patients: analysis of the randomized trials. Ann Thorac Surg. 2004 Feb;77(2):635-42; discussion 642-3.

2003 -- Pubmed # 14638172 -- Allen LaPointe NM, Kramer JM, Hammill BG, Chen A, DeLong ER, Ricketts RK, Muhlbaier LH, McCants CB, Califf RM. Long-term adherence to evidence-based therapies for coronary artery disease and heart failure in the outpatient setting. J Am Coll Cardiol. 2003 Mar 19;41(6 Suppl B):517.

2003 -- Pubmed # 12939241 -- Califf RM, Muhlbaier LH. Health Insurance Portability and Accountability Act (HIPAA): must there be a trade-off between privacy and quality of health care, or can we advance both? Circulation. 2003 Aug 26;108(8):915-8.

2002 -- Pubmed # 11988192 -- Allen LaPointe NM, Kramer JM, DeLong ER, Ostbye T, Hammill BG, Muhlbaier LH, McCants CB, Chen A, Califf RM. Patient-reported frequency of taking aspirin in a population with coronary artery disease. Am J Cardiol. 2002 May 1;89(9):1042-6.

2002 -- Pubmed # 11897205 -- Califf RM, DeLong ER, Ostbye T, Muhlbaier LH, Chen A, LaPointe NA, Hammill BG, McCants CB, Kramer JM. Underuse of aspirin in a referral population with documented coronary artery disease. Am J Cardiol. 2002 Mar 15;89(6):653-61.

2002 -- Muhlbaier, L.H. (2002).  HIPAA Training Handbook for Researchers:  HIPAA and Clinical Trials.  Opus Communications, Inc., Marblehead, MA.

2001 -- "Guidelines for Academic Medical Centers on security and privacy:  practical strategies for addressing the Health Insurance Portability and Accountability Act" May, 2001.  Member of  writing workgroup.

2001 -- Pubmed # 11691517 -- Cowper PA, Peterson ED, DeLong ER, Wightman MB, Wawrzynski RP, Muhlbaier LH, Sketch MH. The impact of statistical adjustment on economic profiles of interventional cardiologists. J Am Coll Cardiol. 2001 Nov 1;38(5):1416-23.

2001 -- Pubmed # 11153183 -- Saur CD, Granger BB, Muhlbaier LH, Forman LM, McKenzie RJ, Taylor MC, Smith PK. Depressive symptoms and outcome of coronary artery bypass grafting. Am J Crit Care. 2001 Jan;10(1):4-10.

2000 -- Pubmed # 10716477 -- Alexander KP, Anstrom KJ, Muhlbaier LH, Grosswald RD, Smith PK, Jones RH, Peterson ED. Outcomes of cardiac surgery in patients > or = 80 years: results from the National Cardiovascular Network. J Am Coll Cardiol. 2000 Mar 1;35(3):731-8.

2000 -- Pubmed # 11127458 -- Peterson ED, DeLong ER, Muhlbaier LH, Rosen AB, Buell HE, Kiefe CI, Kresowik TF. Challenges in comparing risk-adjusted bypass surgery mortality results: results from the Cooperative Cardiovascular Project. J Am Coll Cardiol. 2000 Dec;36(7):2174-84.

2000 -- Pubmed # 10650291 -- Peterson ED, Lansky AJ, Anstrom KJ, Muhlbaier LH, Popma JJ, Satler LF, Lanzilotta MJ. Evolving trends in interventional device use and outcomes: results from the National Cardiovascular Network Database. Am Heart J. 2000 Feb;139(2 Pt 1):198-207.

1999 -- Pubmed # 10197656 -- Milano CA, Georgiade G, Muhlbaier LH, Smith PK, Wolfe WG. Comparison of omental and pectoralis flaps for poststernotomy mediastinitis. Ann Thorac Surg. 1999 Feb;67(2):377-80; discussion 380-1.

1998 -- Pubmed # 9768723 -- Peterson ED, DeLong ER, Jollis JG, Muhlbaier LH, Mark DB. The effects of New York's bypass surgery provider profiling on access to care and patient outcomes in the elderly. J Am Coll Cardiol. 1998 Oct;32(4):993-9.

1998 -- Pubmed # 9778327 -- Shaw LJ, Peterson ED, Shaw LK, Kesler KL, DeLong ER, Harrell FE Jr, Muhlbaier LH, Mark DB. Use of a prognostic treadmill score in identifying diagnostic coronary disease subgroups. Circulation. 1998 Oct 20;98(16):1622-30.

1997 -- Pubmed # 9421867 -- DeLong ER, Peterson ED, DeLong DM, Muhlbaier LH, Hackett S, Mark DB. Comparing risk-adjustment methods for provider profiling. Stat Med. 1997 Dec 15;16(23):2645-64.

1997 -- Pubmed # 9431795 -- Smith PK, Smith LR, Muhlbaier LH. Risk stratification for adverse economic outcomes in cardiac surgery. Ann Thorac Surg. 1997 Dec;64(6 Suppl):S61-3; discussion S80-2.

1995 -- Pubmed # 7586468 -- Peterson ED, Cowper PA, Jollis JG, Bebchuk JD, DeLong ER, Muhlbaier LH, Mark DB, Pryor DB. Outcomes of coronary artery bypass graft surgery in 24,461 patients aged 80 years or older. Circulation. 1995 Nov 1;92(9 Suppl):II85-91.

1994 -- Mark DB, Nelson CL, Califf RM, Harrell FE, Lee KL, Jones RH, Fortin DF, Stack RS, Glower DD, Smith LR, DeLong ER, Smith PK, Reves JG, Jollis JG, Tcheng JE, Muhlbaier LH, Lowe JE, Phillips HR, Pryor DB. Continuing evolution of therapy for coronary artery disease: Initial results from the era of coronary angioplasty. Circulation 1994;89:2015-2025.

1994 -- Pryor DB, Shaw L, McCants CB, Lee KL, Mark DB, Harrell FE Jr., Muhlbaier LH, Califf RM. Value of the history and physical examination in the identifying patients at increased risk for coronary artery disease. Annals of Internal Medicine 1993;118:81-90.

1992 -- Pubmed # 1424000 -- Muhlbaier LH, Pryor DB, Rankin JS, Smith LR, Mark DB, Jones RH, Glower DD, Harrell FE Jr, Lee KL, Califf RM. Observational comparison of event-free survival with medical and surgical therapy in patients with coronary artery disease. 20 years of follow-up. Circulation. 1992 Nov;86(5 Suppl):II198-204.

1992 -- Smith LR, Harrell FE Jr., Muhlbaier LH. Problems and potentials in modeling survival. Medical In Effectiveness Research Data Methods (Summary Report), U.S. Dept. of Health and Human Services, 1992:151-159

1991 -- Pubmed # 2029012 -- Pryor DB, Shaw L, Harrell FE Jr, Lee KL, Hlatky MA, Mark DB, Muhlbaier LH, Califf RM. Estimating the likelihood of severe coronary artery disease. Am J Med. 1991 May;90(5):553-62.

1990 -- Pubmed # 2254801 -- Harrell FE Jr, Marcus SE, Layde PM, Broste SK, Cook EF, Wagner DP, Muhlbaier LH, Peck SL. Statistical methods in SUPPORT. J Clin Epidemiol. 1990;43 Suppl:89S-98S.

1989 -- Pubmed # 2784512 -- Califf RM, Harrell FE Jr, Lee KL, Rankin JS, Hlatky MA, Mark DB, Jones RH, Muhlbaier LH, Oldham HN Jr, Pryor DB. The evolution of medical and surgical therapy for coronary artery disease. A 15-year perspective. JAMA. 1989 Apr 14;261(14):2077-86.

1989 -- Pubmed # 2768730 -- Muhlbaier LH, Pryor DB. Data for cardiovascular modeling. J Am Coll Cardiol. 1989 Sep;14(3 Suppl A):60A-64A.

1989 -- Pubmed # 2747301 -- Parkerson GR Jr, Michener JL, Wu LR, Finch JN, Broadhead WE, Muhlbaier LH, Magruder-Habib K, Helms MJ, Kertesz JW, Clapp-Channing N. The effect of a telephone family assessment intervention on the functional health of patients with elevated family stress. Med Care. 1989 Jul;27(7):680-93.

1989 -- Pubmed # 2785165 -- Parkerson GR Jr, Michener JL, Wu LR, Finch JN, Muhlbaier LH, Magruder-Habib K, Kertesz JW, Clapp-Channing N, Morrow DS, Chen AL. Associations among family support, family stress, and personal functional health status. J Clin Epidemiol. 1989;42(3):217-29.

1988 -- Pubmed # 3261657 -- Califf RM, Harrell FE Jr, Lee KL, Rankin JS, Mark DB, Hlatky MA, Muhlbaier LH, Wechsler AS, Jones RH, Oldham HN Jr. Changing efficacy of coronary revascularization. Implications for patient selection. Circulation. 1988 Sep;78(3 Pt 2):I185-91.

1988 -- Pubmed # 3390813 -- Friedman HS, Colvin OM, Skapek SX, Ludeman SM, Elion GB, Schold SC Jr, Jacobsen PF, Muhlbaier LH, Bigner DD. Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. Cancer Res. 1988 Aug 1;48(15):4189-95.

1987 -- Pubmed # 3499256 -- Pryor DB, Harrell FE Jr, Rankin JS, Lee KL, Muhlbaier LH, Oldham HN, Hlatky MA, Mark DB, Reves JG, Califf RM. The changing survival benefits of coronary revascularization over time. Circulation. 1987 Nov;76(5 Pt 2):V13-21.

1986 -- Pubmed # 3746488 -- Deubner DC, MacCormack JN, Kleeman K, Muhlbaier LH. One-time screening to define the problem: Legionella exposure in an electric power company. J Occup Med. 1986 Aug;28(8):670-3.

1981 -- Pubmed # 7278417 -- Parkerson GR Jr, Gehlbach SH, Wagner EH, James SA, Clapp NE, Muhlbaier LH. The Duke-UNC Health Profile: an adult health status instrument for primary care. Med Care. 1981 Aug;19(8):806-28.

1979 -- Pubmed # 759744 -- Thacker SB, Salber EJ, Osborne C, Muhlbaier LH. Primary care in Durham County: who gives care to whom? Med Care. 1979 Jan;17(1):69-78.