James Rochon, Ph.D.

Department:
Biostatistics and Bioinformatics

Email Address:
James.Rochon@duke.edu

Address:
Box 3850
DUMC
Durham, NC 27710

Telephone:
9196688123

Fax Telephone:
9196687055

Research Interests:
Dr. Rochon received his Ph.D. in Biostatistics from the University of North Carolina at Chapel Hill in 1985. He is a experienced biomedical investigator, and over the years has gained considerable experience from a variety of medical studies. He has been an active collaborator in the fields of inflammatory bowel disease and human transplantation, leading to publications in the New England Journal of Medicine, Journal of Immunology, Transplantation and elsewhere.

From 1994 to 2002, he was an Associate Research Professor at the Biostatistics Center of the George Washington University. He collaborated on a number of large, multi-center clinical trials under the direction of senior biostatistical investigators including Drs. John Lachin and Ray Bain. In July, 2002, he joined the faculty at the Duke Clinical Research Institute (DCRI) as a Research Professor.

Dr. Rochon is currently serving as the Principal Investigator for the CALERIE Coordinating Center. This study, funded by the National Institute on Aging, is investigating the effects of calorie-restricted (CR) diets on the aging process. The primary goals are to gain knowledge on the effects of sustained CR on physiology, metabolism, body composition, and various risk factors for age-related pathologies. He is also serving as the Principal Investigator for the Coordinating Center of the Drug-Induced Liver Injury Network (DILIN), funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This network is performing epidemiological studies into the genetic and clinical risk factors associated with liver injury caused by prescription drugs and herbal medicines. From 1999 to 2002, Dr. Rochon served as the Principal Investigator for the Coordinating Center for the Girls health Enrichment Multi-site Studies (GEMS), funded by the National Heart, Lung, and Blood Institute (NHLBI).

Dr. Rochon has also served as the Principal Investigator for a research grant funded by the National Cancer Institute (NCI).Its purpose was to develop statistical methodologies for the design and analysis of longitudinal studies. Papers from this grant were published in Biometrics, Journal of the American Statistical Association, Journal of the Royal Statistical Society and elsewhere.

Publications:
2009 -- Pubmed # 19132805 -- Fontana RJ, Watkins PB, Bonkovsky HL, Chalasani N, Davern T, Serrano J, Rochon J, . Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct. Drug Saf. 2009;32(1):55-68.

2008 -- Pubmed # 18955056 -- Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J, . Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4.

2008 -- Pubmed # 19179834 -- Gilhooly CH, Das SK, Golden JK, McCrory MA, Rochon J, DeLany JP, Freed AM, Fuss PJ, Dallal GE, Saltzman E, Roberts SB. Use of cereal fiber to facilitate adherence to a human caloric restriction program. Aging Clin Exp Res. 2008 Dec;20(6):513-20.

2008 -- Pubmed # 18798340 -- Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG, . Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury. Hepatology. 2008 Oct;48(4):1175-83.

2005 -- Pubmed # 16239128 -- Haqq AM, Lien LF, Boan J, Arlotto M, Slentz CA, Muehlbauer MJ, Rochon J, Gallup D, McMahon RL, Bain JR, Stevens R, Millington D, Butler MD, Newgard CB, Svetkey LP. The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design. Contemp Clin Trials. 2005 Dec;26(6):616-25.

2004 -- Pubmed # 15072857 -- Cullen KW, Klesges LM, Sherwood NE, Baranowski T, Beech B, Pratt C, Zhou A, Rochon J. Measurement characteristics of diet-related psychosocial questionnaires among African-American parents and their 8- to 10-year-old daughters: results from the Girls' health Enrichment Multi-site Studies. Prev Med. 2004 May;38 Suppl:S34-42.

2004 -- Pubmed # 15702199 -- Dahmen G, Rochon J, König IR, Ziegler A. Sample size calculations for controlled clinical trials using generalized estimating equations (GEE). Methods Inf Med. 2004;43(5):451-6.

2004 -- Pubmed # 15468767 -- Rochon J. Using a serial marker to predict a repeated measures outcome in a cohort design--results of a simulation study. J Biopharm Stat. 2004 Aug;14(3):817-33.

2003 -- Pubmed # 12713207 -- Rochon J, Klesges RC, Story M, Robinson TN, Baranowski T, Obarzanek E, Mitchell M. Common design elements of the Girls health Enrichment Multi-site Studies (GEMS). Ethn Dis. 2003;13(1 Suppl 1):S6-14.

2003 -- Pubmed # 12729395 -- Rochon J. Using a serial marker to predict a repeated measures outcome in a cohort study. J Biopharm Stat. 2003 May;13(2):283-300.

2003 -- Pubmed # 12713213 -- Story M, Sherwood NE, Obarzanek E, Beech BM, Baranowski JC, Thompson NS, Owens AS, Mitchell M, Rochon J. Recruitment of African-American pre-adolescent girls into an obesity prevention trial: the GEMS pilot studies. Ethn Dis. 2003;13(1 Suppl 1):S78-87.

2001 -- Pubmed # 11304734 -- Rochon J, Gillespie BW. A methodology for analysing a repeated measures and survival outcome simultaneously. Stat Med. 2001 Apr 30;20(8):1173-84.

1999 -- Rochon J. Issues in adjusting for covariates arising post randomization in clinical trials. Drug Information Journal 1999; 33:1219-1228.

1998 -- Pubmed # 9699236 -- Rochon J. Application of GEE procedures for sample size calculations in repeated measures experiments. Stat Med. 1998 Jul 30;17(14):1643-58.

1996 -- Rochon J. Accounting for covariates observed post randomization for discrete and continuous repeated measures data. Journal of the Royal Statistical Society, Series B 1996; 58:205-219.

1995 -- Pubmed # 7816064 -- Feagan BG, Rochon J, Fedorak RN, Irvine EJ, Wild G, Sutherland L, Steinhart AH, Greenberg GR, Gillies R, Hopkins M. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. N Engl J Med. 1995 Feb 2;332(5):292-7.

1994 -- Pubmed # 8196727 -- Feagan BG, McDonald JW, Rochon J, Laupacis A, Fedorak RN, Kinnear D, Saibil F, Groll A, Archambault A, Gillies R. Low-dose cyclosporine for the treatment of Crohn's disease. The Canadian Crohn's Relapse Prevention Trial Investigators. N Engl J Med. 1994 Jun 30;330(26):1846-51.

1989 -- Pubmed # 2655730 -- Rochon J, Helms RW. Maximum likelihood estimation for incomplete repeated-measures experiments under an ARMA covariance structure. Biometrics. 1989 Mar;45(1):207-18.

1989 -- Pubmed # 2655729 -- Rochon J. The application of the GSK method to the determination of minimum sample sizes. Biometrics. 1989 Mar;45(1):193-205.