William Wilkinson, PhD

Department:
Biostatistics and Bioinformatics

Email Address:
william.wilkinson@duke.edu

Address:
DUMC Box 2734

Durham, NC 27710

Telephone:
9196814561

Fax Telephone:
9196814569

Research Interests:
Paroxysmal supraventricular arrhythmias are common abnormalities of the heart in which patients experience sudden and seemingly unpredictable changes in the cardiac rhythm.  Stochastic process models describing the recurrent behavior of these arrhythmias have important applications in the design and analysis of clinical trials evaluating the efficacy of antiarrhythmic drugs and implantable defibrillators.  Of particular interest at the present time is the development of mixture models which more accurately describe the distribution of first-recurrence times in groups of patients and the development of model-specific analytic techniques which can be used to evaluate treatment effects in the context of randomized clinical trials.

Publications:
1999 -- Pritchett ELC, Wilkinson WE. Effect of dofetilide on survival in patients with supraventricular arrhythmias. Am Heart J 138: 994-997, 1999.

1993 -- Clair WK, Wilkinson WE, McCarthy EA, Page RL, Pritchett ELC. Spontaneous occurrence of symptomatic paroxysmal atrial fibrillation and paroxysmal supraventricular tachycardia in untreated patients. Circulation 87:1114-1122, 1993.

1990 -- Obrist WD, Wilkinson WE: Regional cerebral blood flow measured by Xenon-133 clearance in man. Cerebrovascular and Brain Metabolism Reviews 2:283-327, 1990.

1975 -- Obrist WD, Thompson HK, Wang HS, Wilkinson WE: Regional cerebral blood flow estimated by Xenon-133 inhalation. Stroke 6:245-256, 1975.

1969 -- Smith WL, Wilkinson WE: On branching processes in random environments. Ann Math Statist 40:814-827, 1969.