High-Throughput Sequencing Course

The Department of Biostatistics and Bioinformatics will offer a summer High Throughput Sequencing Course from May 20th to June 27th, 2019 at Duke University.  Genomics technologies are advancing at an exponential rate, and the ability to run genomic experiments and analyze the resulting data is a critical skill set for future researchers in biology and medicine. Due to the complexity of the genome and the vast quantities of data generated per experiment, making sense of genomic data poses unique statistical and computational challenges. As part of the National Institutes of Health (NIH) Big Data to Knowledge (BD2K) initiative, the Department of Biostatistics and Bioinformatics, together with faculty from the Duke Center for Genomic and Computational Biology, was again funded to host a 6-week summer course on High Throughput Sequencing (HTS). Our goal is to teach the next generation of scientists the biological,  statistical, computational and informatics knowledge for implementing a well-designed genomics experiment.

Topics covered in the summer course include:

  • Introduction to molecular biology and HTS
  • Laboratory sessions generating and preparing RNA for HTS
  • Data munging, analysis and visualization in R
  • Statistical concepts for experimental design
  • Hypothesis testing and sample size calculations
  • Unsupervised and supervised statistical learning
  • Multiple testing, missing data, pathway and meta-analysis
  • Pipelines for HTS analysis using the Unix shell and R/Bioconductor
  • Data standards and informatics resources for HTS

Course Schedule:  

The course meets 9AM - 4PM Monday - Thursday, except for week two.  Memorial Day is on the Monday of week two, so that week classes will be held 9AM - 4PM Tuesday - Friday.  Here is a summary schedule:
Week Dates Days
1 5/20-5/23 Mon, Tues, Wed, Thurs
2 5/28-5/31 Tues, Wed, Thurs, Fri
3 6/03-6/06 Mon, Tues, Wed, Thurs
4 6/10-6/13 Mon, Tues, Wed, Thurs
5 6/17-6/20 Mon, Tues, Wed, Thurs
6 6/24-6/27 Mon, Tues, Wed, Thurs

To Apply:

Applications are no longer being accepted for the summer session of 2019. It is likely that a similar course will be offered in the summer of 2020.  Please check on the website for further updates. 

Applicants seeking admission must submit the online application form and provide two letters of recommendation. The recommendations should be written by someone qualified to testify to your capacity for graduate work. The recommendation form is also an online form.

  • Tuition is free to all participants. 
  • Class is held Monday through Thursday from 9:00am - 4:00pm. Lunch break 11:45 - 1:45. There are no classes Friday, Saturday and Sunday. 



 If you have additional questions, please contact the course coordinator at: htscourse@duke.edu 

Course Flyer

Course Instructors