Labs

Raluca Gordan Lab

The Gordan lab studies the mechanisms by which transcription factors are recruited to their specific DNA sites, both in vitro and in vivo, and how this recruitment is affected by changes in the DNA or protein sequence. We use protein binding microarray assays and computational approaches that combine different types of information relevant for DNA binding and transcriptional regulation.

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Tim Reddy Lab

Tim Reddy is an Assistant Professor in the Duke Center for Genomic & Computational Biology and the Department of Biostatistics & Bioinformatics. He holds a secondary appointment in Biomedical Engineering and the Department of Molecular Genetics & Microbiology. The Reddy Lab is focused on understanding how genetic variation that alters gene regulation contributes to human traits including risk for common diseases such as diabetes. Several large association studies have revealed genetic variants that influence human traits.  What is not known is the mechanisms involves. Because most of these trait-associated variants are found far away from genes, we hypothesize that they act by altering the regulation of nearby genes. To test this hypothesis, we use an interdisciplinary combination of high-throughput genomics, computational biology, and traditional molecular biology and genetics experiments. We hope that, through our research, we can better understand the gene-regulatory bases for human evolution and human disease. Those findings will likely reveal new pathways of disease that can ultimately be targeted for novel diagnostics and treatment.

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