eQTL mapping using RNA-seq data, assumptions, implementations, and cautions

Seminar Series

Friday, October 11, 2019 - 01:00
MSRB 3 1125 Seminar Room
Wei Sun, PhD

Using information from allele-specific gene expression (ASE) can sub-stantially improve the power for mapping gene expression quantitative trait loci (eQTL). A few methods have been proposed towards this end. We compare these methods and demonstrate the limitations and ad-vantages of each method. We will also discuss our recent work on cell type-specific eQTL mapping to identify cell type-specific eQTLs using bulk tissue gene expression data and estimated cell type proportions.

Wei Sun, PhD
Member, Biostatistics Program
Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Seattle, Washington