Here are summaries of a selection of the papers published by GCB faculty in August 2021:
CANCER
Xiling Shen, Greg Crawford, Charlie Gersbach, Purushothama Rao Tata and team investigated chromatin remodeling in metastatic cells in the liver and present a potential strategy to target that chromatic remodeling in metastatic cancer and the promise of repurposing drugs to treat metastasis. Read more
David Hsu collaborated with UNC Chapel Hill to investigate sites of DNA damage and repair following anti-cancer drug treatments. They mapped these sites genome wide at single nucleotide resolution and as a function of circadian time. This data might help provide valuable information for creating rational chronochemotherapy regimens. Read more
Ashley Chi was part of a team that investigated the role of Serine/Threonine Kinase 3 (STK3). Their data suggests that STK3 has a non-canonical pro-tumorigenic role in prostate cancer, which may be targeted by small molecule inhibitors to reduce prostate cancer growth and progression. Read more
CELL REPAIR
Anne Yoder part of a team that took fibroblast cell lines from mouse lemur, exposed them to UV irradiation and analyzed the repair events genome-wide. Read more
DISEASE
Doug Marchuk and team identified genes that influence infarct volume, the critical outcome of ischemic stroke, by using a surgically induced mouse model of ischemic stroke and subsequent QTL mapping analysis. Read more
Ornit Chiba-Falek, Greg Crawford, Raluca Gorân and team used ATAC-seq profiling from frozen brain tissues to determine late-onset Alzheimer’s disease-specifif changes in chromatin accessibility landscape. Read more
NEW METHODS & MODELS
Charlie Gersbach, Tim Reddy and team developed two new transgenic mouse lines for targeted gene regulation using dCas9 in vivo. They demonstrated the flexibility, versatility and robustness of these mouse lines through a variety of experiments. The mice are publicly available through The Jackson Laboratory. Read more
SEQUENCING
Amy Goldberg was part of a team that resequenced Eurasian pigs from nine Asian and European breeds. This work showed the evolutionary history of pigs through the lens of the Y chromosome. Read more