Here are summaries of a selection of the papers published by GCB faculty in January 2020:
ANTIBIOTIC RESISTANCE
Lingchong You and team showed that at least 25 percent of antibiotic-resistant pathogenic bacteria found in clinical settings are capable of spreading their resistance directly to other bacteria. Despite common beliefs, though, using antibiotics does not significantly affect the rate at which the genes responsible for resistance are swapped between bacteria. Read more
REGULATION
Greg Crawford was part of a team that characterized expression and chromatin state dynamics across liver, lung and kidney tissues in 47 strains of the Collaborative Cross (CC) mouse population to examine the regulation of these dynamics by expression quantitative trait loci and chromatin QTL. Read more
Ashley Chi and team report that RIPK3 is highly expressed in recurrent breast tumors and is required for productive proliferation. However, this exaggerated reexpression of RIPK3 also renders the recurrent tumor cells vulnerable to cell death triggered by cystine deprivation. Thus, RIPK3-depenent proliferation of recurrent tumor cells creates the collateral vulnerability to cystine deprivation that can serve as a novel therapeutic strategy for recurrent tumors. Read more
REVIEWS
Lingchong You along with Kyeri Kim reviewed research by Brandon Schlomann, et al. that describes how sublethal antibiotics can trigger the purging of bacteria by the zebrafish. Read more