Here are summaries of a selection of the papers published by GCB faculty in June 2019:
REGULATION
To better understand the regulatory mechanisms of genome-wide association study (GWAS) loci affecting adipose tissue, Greg Crawford was part of a team that profiled chromatin accessibility in three frozen human subcutaneous adipose tissue needle biopsies and preadipocytes and adipocytes from the Simpson Golabi-Behmel Syndrome cell strain using an ATAC-seq. Read more
Sayan Mukherjee collaborated with Merve Cakir and Kris Wood to determine genes that are frequently altered in the Cancer Genome Atlas patient populations, then examined the effects of these alterations on signaling and regulatory pathways using a label propagation-based methodology to generate networks from gene expression signatures associated with defined mutations. Read more
Amy Schmid was part of a team that investigated the importance of Halobacterium salinarum archaellin N-glycosylation as compared to a parent strain and in cells lacking aglB. Read more
DISEASE
Doug Marchuk was part of a team that explored whether levels of plasma molecules previously implicated in disease mechanisms could act as a diagnostic biomarker in patients with cerebral cavernous malformations who have experience a symptomatic hemorrhage within the past year. Read more
Ornit Chiba Falek, along with Michael Lutz and Daniel Sprague, developed a bioinformatics pipeline to advance the interpretation of Alzheimer’s disease genome wide association studies discoveries. Read more
Greg Wray, Greg Crawford and team investigated how humans became the “fat primate” by comparing fat samples from humans, chimps and rhesus macaques. Using ATAC-seq, they scanned each species’ genome for differences in how their fat cell DNA is packaged. Read more
MICROBIOME/GUT HEALTH
John Rawls was part of a team that identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention. Read more
Jennifer Wernegreen collaborated with Bryan Brown to bring into culture and characterize two closely-related strains of gut associated Acetobacteraceae (AAB) of the red carpenter ant, Camponotus chromaiodes. Read more
MODELS/METHODS
Lingchong You was part of a team that developed a de novo engineered model system of genetically engineered biomolecular condensates that prevent translation within droplet-based protocells. Read more
Dave MacAlpine, along with Monica Gutierrez and Heather MacAlpine developed nascent chromatin occupancy profiles to comprehensively profile nascent and mature chromatin at nucleotide resolution. Read more
REVIEWS
Susanne Haga considers current and potential approaches to guiding primary care providers to navigate the ever-growing and rapidly changing of genomic medicine to help patients better understand their own genomic information. Read more