Seminar Series

The Applied Biostatistics Seminar Series consists of a series of talks with the primary purpose of furthering statistical knowledge on an applied level. Talks will focus on advances in biostatistical methods and statistical programming techniques and their translation into addressing biomedical research questions. The seminars are open to all members of the Duke community, but primarily geared toward applied statistical researchers.

Multicellular synthetic biology: Understanding the design principles of intercellular communication

Michael Bennett, PhD
Monday, October 18, 2021 - 12:00 at Zoom

Abstract: Synthetic biologists have long sought to rationally engineer genetic regulatory networks for a variety of reasons. For instance, the basic science of understanding gene regulation has prospered due to our ability to intricately construct, perturb, and monitor gene networks in living cells. Further, synthetic biologists have designed a host...
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Methods for combining experimental and population data to estimate population average treatment effects

Elizabeth Stuart, PhD
Friday, October 15, 2021 - 03:30 at Zoom

Abstract: With increasing attention being paid to the relevance of studies for real-world practice (such as in education, international development, and comparative effectiveness research), there is also growing interest in external validity and assessing whether the results seen in randomized trials would hold in target populations. While randomized trials yield...
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Some open problems in causal mediation pathway analyses

Peter Song, PhD
Friday, October 8, 2021 - 12:00 at Zoom

Abstract : Mediation analysis is a pervasive methodology in biomedical studies to help understand the mechanistic role of mediators as part of the exposure-response relationship. Through the directed acyclic graphic (DAG) modeling, such an analysis has recently been extended for its capability within the field of causal inference. The existing...
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An optimization perspective on high-dimensional regression problems - with some gut-wrenching applications

Christian Müller, PhD
Friday, September 24, 2021 - 12:00 at Zoom

Abstract: In this talk, I will provide an optimization perspective on solving high-dimensional regression problems. Starting with the idea of concomitant estimation from robust statistics, I will present a unifying optimization model for maximum likelihood-type estimation (M-estimation) relying on the idea of perspective functions. The model encompasses a wide range...
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Health Impacts of the Built Environment and Air Quality Through the Lenses of Epigenetics and Electronic Health Records”

Friday, September 24, 2021 - 12:00 at Zoom

Environmental epidemiology is being rapidly transformed by the wealth of data now available. Electronic health records are empowering studies of vulnerable patient populations with sample sizes and depths of clinical phenotyping previously unavailable. Meanwhile molecular data allow researchers to investigate the molecular effects of pollutants in human populations, generating novel...
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