Seminar Series

The Applied Biostatistics Seminar Series consists of a series of talks with the primary purpose of furthering statistical knowledge on an applied level. Talks will focus on advances in biostatistical methods and statistical programming techniques and their translation into addressing biomedical research questions. The seminars are open to all members of the Duke community, but primarily geared toward applied statistical researchers.

The Challenges of Research at Scale

Monday, June 10, 2019 - 02:00 at CRTP Classroom 2nd Floor Hock Plaza

Early lessons from building a platform for 1M participants and 300K researchers. Verily Life Sciences The mission of Verily, an Alphabet company, is to make the world’s health data useful so that people enjoy longer and healthier lives. We are developing tools and devices to collect, organize and activate health...
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Fetal Fraction and Statistical Power in Noninvasive Prenatal screening

Tuesday, May 14, 2019 - 12:00 at MSRBIII Seminar Room

Abstract: In the noninvasive prenatal screen (NIPS) the cell-free DNA (cfDNA) in maternal plasma is sequenced. As some cfDNA circulating in the plasma of a pregnant woman is from her fetus, NIPS can detect some genetic abnormalities in the fetus. For example, fetal trisomy can be detected by estimating a...
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Scalable Methods for Understanding the Genetic Architecture of Complex Traits

Friday, March 22, 2019 - 11:00 at MSRB III 1125

Thanks to the decreasing cost of sequencing and improved statistical methods for genotype imputation, it is now possible to aggregate large datasets with millions of individuals to study the genetics of complex traits. Previous studies on the smoking and drinking addictions were hampered by the lack of power and very...
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Quantifying Gerrymandering or A Mathematician Goes to Court

Jonathan C. Mattingly, PhD
Friday, February 22, 2019 - 12:00 at MSRB1 #001 Seminar Room

Abstract: In October 2017, I found myself testifying for hours in a Federal court. I had not been arrested. Rather I was attempting to quantify gerrymandering using a mathematical analysis which grew from asking if a surprising 2012 election was in fact, surprising. It hinged on probing the geopolitical structure...
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Measuring the mortality reductions produced by organized cancer screening: a principled approach

James A Hanley, PhD
Friday, February 1, 2019 - 12:00 at MSRB1 #001 Seminar Room

Abstract: In cancer screening trials, or in comparisons involving regions that did/did not introduce population-based screening programs, the mortality reductions are usually summarized by an overall (single-number) mortality reduction. But this overall mortality reduction is an average of minimal reductions in the first years, larger ones after some years, waning...
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