Seminar Series

The Applied Biostatistics Seminar Series consists of a series of talks with the primary purpose of furthering statistical knowledge on an applied level. Talks will focus on advances in biostatistical methods and statistical programming techniques and their translation into addressing biomedical research questions. The seminars are open to all members of the Duke community, but primarily geared toward applied statistical researchers.

Mapping robust trans-associations via cross-condition mediation analyses and validating trait-associations of trans-genes for GWAS SNPs

Lin Chen, PhD
Friday, September 6, 2019 - 10:00 at 8065 Hock Plaza

Abstract: Trans-eQTLs explain a substantial proportion of expression variation, yet are challenging to be detected and replicated since their effects often act in a tissue-specific manner. Many trans-effects are mediated via cis-gene expression and some of those effects are shared across tissue types/conditions. In order to detect robust cis-mediated trans-associations,...
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Graphical Models for Gene Regulation

Wednesday, August 7, 2019 - 11:00 at MSRB III 1125

Abstract: Probabilistic graphical models provide a flexible means of integrating multiple sources of information while accounting for known dependencies and other prior knowledge. Implementing such models is now considerably easier than before, due to the availability of frameworks such as STAN that automate the inference task for a given model...
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The Challenges of Research at Scale

Monday, June 10, 2019 - 02:00 at CRTP Classroom 2nd Floor Hock Plaza

Early lessons from building a platform for 1M participants and 300K researchers. Verily Life Sciences The mission of Verily, an Alphabet company, is to make the world’s health data useful so that people enjoy longer and healthier lives. We are developing tools and devices to collect, organize and activate health...
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Fetal Fraction and Statistical Power in Noninvasive Prenatal screening

Tuesday, May 14, 2019 - 12:00 at MSRBIII Seminar Room

Abstract: In the noninvasive prenatal screen (NIPS) the cell-free DNA (cfDNA) in maternal plasma is sequenced. As some cfDNA circulating in the plasma of a pregnant woman is from her fetus, NIPS can detect some genetic abnormalities in the fetus. For example, fetal trisomy can be detected by estimating a...
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Scalable Methods for Understanding the Genetic Architecture of Complex Traits

Friday, March 22, 2019 - 11:00 at MSRB III 1125

Thanks to the decreasing cost of sequencing and improved statistical methods for genotype imputation, it is now possible to aggregate large datasets with millions of individuals to study the genetics of complex traits. Previous studies on the smoking and drinking addictions were hampered by the lack of power and very...
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