What do you do if you’re being chased by a bear? Run! How do you do it? With a little help from cortisol – a hormone that regulates part of the body’s response to stress. Cortisol reduces inflammation in your joints and mobilizes glucose into your body to give your muscles energy to run.
Gersbach lab study directly converts mouse fibroblasts into neuronal cells with CRISPR-based gene activation
A new study suggests that CRISPR/Cas9 can help cells be reprogrammed from one type to another directly, without first inducing pluripotency. It's another step towards the ability to precisely modify the epigenomic landscape in cells.
Allison Lopatkin, a doctoral student in Dr. Lingchong You’s laboratory, is the lead author of a new study published online in Nature Microbiology that turns assumptions about the cause of antibiotics resistance on its head and suggests new directions for antibiotic use.
Dr. Lawrence David is one of several to be named a 2015 Beckman Young Investigator for his work using natural bacterial interactions to control microbial communities. The Beckman Young Investigator Program aims at providing research support to the most promising young faculty members in the early stages of their academic careers.
GCB researcher Charlie Gersbach and his team have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy. Gersbach, Fellow Chris Nelson, and colleagues collaborated with researchers at UNC-Chapel Hill, the University of Missouri School of Medicine, and the Broad Institute/Harvard to package CRISPR/Cas-9 into the virus AAV to deliver the gene editing tools into an adult mouse. The virus cut out the defective sections of the dystrophin gene from cells throughtout the mouse's body, enabling the gene to produce functional proteins.
GCB's Avsholom Caspi and Terrie Moffitt and colleagues have identified multiple health factors that may be combined to determine whether people are aging faster or slower than their peers. Using data collected from the Dunedin Study, a longitudinal study that has followed more than 1,000 people in New Zealand from birth to the present, the authors found that study participants who were "biologically older" than their peers had exhibited signs of aging as indicated in tests such HDL cholesterol, cardiorespiratory fitness, telomere length, dental health, and other biomarkers.
Lingchong You's lab has published a paper in Nature that suggests a cell will take longer to grow if it's initial size was smaller. They have found a simple linear relationship between the initial cell cell and its final size before division. This refutes recent publications suggesting that cells in the body add the same amount of mass before they divide. Fellow GCB researcher Nick Buchler and members of his lab participated in the study. Read more here.
GCB researchers Greg Crawford, Tim Reddy, and Charlie Gersbach are part of a multi-institutional collaborative effort funded by the March of Dimes Foundation to study factors that contribute to premature birth. Crawford, Reddy, Gersbach, and colleagues will study the gene regulatory elements utilized in full-term and pre-term pregnancies and characterize how stress, pregnancy relevant hormones, and genetic variation impact the function of these elements.
Seven Duke undergraduates worked with GCB faculty members Charles Gersbach and Nicholas Buchler to develop a synthetic molecular circuit that was awarded a coveted gold medal at the 2014 international iGEM competition featuring over 100 teams.